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Interestingly, in cats, there was no change in serum concentrations of homocysteine (see Figure 1)

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Haghighi SS, Zhang R, Stein D

This distinction suggests that early DDAVP administration in the proactive group might have facilitated controlled sodium correction once the underlying causes of hyponatremia were addressed, often eliminating the need for further doses on the second day, contrasting with the reactive approach where DDAVP administration was based on evolving sodium levels, potentially leading to later interventions